Saturday, March 16, 2013
Niacin?
I am a member of the National Lipid Association (Yes, exciting I know!). This morning I received an email about the newest Niacin study HPS2-THRIVE. The study (using EXTENDED RELEASE Niacin) found that:
"The primary composite endpoint of major vascular events (MVE) was not significantly reduced (risk ratio 0.96, 95% CI: 0.90-1.03, p =0.3) in the active arm. "Serious adverse events" were found in 3% more subjects in the active arm, although most were "minor hyperglycemic problems." Myopathy generally was uncommon (0.34%/yr), but was 4-fold higher overall in the active arm, and 10-fold higher among Chinese subjects."
Regardless, the NLA believes that, "Meanwhile, we believe that niacin remains a valuable adjunct to statin treatment for LDL-C lowering, and a valuable statin alternative in statin intolerant patients."
The bottom line is that for years we have known that Extended Release Niacin increases your risk for liver toxicity and shows little of the cardiovascular benefit that (real, Immediate Release) Niacin shows. If you are intolerant (like most people) of Niacin (Immediate Release), do not expect to get the same health benefits from the extended release preparations.
This illustrates the foundation of the Paleo/Primal movement: If you take real, healthy, natural food and manipulate it in a lab, do not expect to get the same health benefits!
"The primary composite endpoint of major vascular events (MVE) was not significantly reduced (risk ratio 0.96, 95% CI: 0.90-1.03, p =0.3) in the active arm. "Serious adverse events" were found in 3% more subjects in the active arm, although most were "minor hyperglycemic problems." Myopathy generally was uncommon (0.34%/yr), but was 4-fold higher overall in the active arm, and 10-fold higher among Chinese subjects."
Regardless, the NLA believes that, "Meanwhile, we believe that niacin remains a valuable adjunct to statin treatment for LDL-C lowering, and a valuable statin alternative in statin intolerant patients."
The bottom line is that for years we have known that Extended Release Niacin increases your risk for liver toxicity and shows little of the cardiovascular benefit that (real, Immediate Release) Niacin shows. If you are intolerant (like most people) of Niacin (Immediate Release), do not expect to get the same health benefits from the extended release preparations.
This illustrates the foundation of the Paleo/Primal movement: If you take real, healthy, natural food and manipulate it in a lab, do not expect to get the same health benefits!
Tuesday, March 12, 2013
This week it's salt that's in the news!
Another great article by Zoe Harcombe on (another demonized nutrient essential for life) salt!
A sample:
"9) There is no evidence that salt causes heart disease; there is evidence that low salt is associated with heart attacks
A study of approximately 3,000 hypertensive subjects (men with high blood pressure) found that there was a 430% increase in myocardial infarction (heart attack) in the group with the lowest salt intake versus the group with the highest salt intake. (Ref 6) Knowing how vital salt is for human health, this should not be surprising – low-sodium diets have been shown to cause multiple nutrient deficiencies, including nutrients vital for heart health (calcium, magnesium, potassium and B-vitamins). (Ref 7)
The SACN report concluded: “There are insufficient reliable data on long-term effects of salt on cardiovascular disease outcomes to reach clear conclusions.” Quite."
Read the whole thing!
A sample:
"9) There is no evidence that salt causes heart disease; there is evidence that low salt is associated with heart attacks
A study of approximately 3,000 hypertensive subjects (men with high blood pressure) found that there was a 430% increase in myocardial infarction (heart attack) in the group with the lowest salt intake versus the group with the highest salt intake. (Ref 6) Knowing how vital salt is for human health, this should not be surprising – low-sodium diets have been shown to cause multiple nutrient deficiencies, including nutrients vital for heart health (calcium, magnesium, potassium and B-vitamins). (Ref 7)
The SACN report concluded: “There are insufficient reliable data on long-term effects of salt on cardiovascular disease outcomes to reach clear conclusions.” Quite."
Read the whole thing!
Saturday, March 2, 2013
Tuesday, February 26, 2013
A New Review of An Old Study
The Sydney Diet Heart Study was conducted in Australia from 1966-1973. It evaluated substituting "heart healthy" vegetable oils rich in PUFA Omega 6 fatty acids for that known evil ......Saturated fat!
The take home points:
"Advice to substitute polyunsaturated fats for saturated fats is a key component of worldwide dietary guidelines for coronary heart disease risk reduction. However, clinical benefits of the most abundant polyunsaturated fatty acid, omega 6 linoleic acid, have not been established. In this cohort, substituting dietary linoleic acid in place of saturated fats increased the rates of death from all causes, coronary heart disease, and cardiovascular disease. An updated meta-analysis of linoleic acid intervention trials showed no evidence of cardiovascular benefit. These findings could have important implications for worldwide dietary advice to substitute omega 6 linoleic acid, or polyunsaturated fats in general, for saturated fats."
Read the whole thing!
Chalk another one up for the Paleo lifestyle!
The take home points:
"Advice to substitute polyunsaturated fats for saturated fats is a key component of worldwide dietary guidelines for coronary heart disease risk reduction. However, clinical benefits of the most abundant polyunsaturated fatty acid, omega 6 linoleic acid, have not been established. In this cohort, substituting dietary linoleic acid in place of saturated fats increased the rates of death from all causes, coronary heart disease, and cardiovascular disease. An updated meta-analysis of linoleic acid intervention trials showed no evidence of cardiovascular benefit. These findings could have important implications for worldwide dietary advice to substitute omega 6 linoleic acid, or polyunsaturated fats in general, for saturated fats."
Read the whole thing!
Chalk another one up for the Paleo lifestyle!
Friday, February 22, 2013
The Sugar Conspiracy!
This is a great video, taken from a lecture at the University of California, San Francisco by Dr. Lustig, Division of Endocrinology and Metabolism. It's very long, but does an excellent job of explaining how fat became the evil part of our diet and sugar was overlooked, how sugar (hfcs) consumption has closely followed the diabetes and obesity epidemic and the metabolic causes for this.
Highly recommended!
Highly recommended!
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